Next-generation therapies for celiac disease: The gluten-targeted approaches.

Based on increasing knowledge of the pathogenesis of celiac disease, some gluten-targeted approaches have been devised, such as down-regulation of gliadin expression, proteolysis of immunodominant peptides, transamidation of glutamine residues and sequestering of gliadin proteins. The present work critically discusses these experimental therapies, their usefulness, and the results obtained, in order to infer what the next generation of therapies for celiac disease will be.

in Trends in Food Science & Technology, 75:56–71.

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